Research and Teaching Interests
The main focus of my research is to understand the molecular structural basis of the biological activities of proteins. We use Nuclear Magnetic Resonance (NMR) spectroscopy, Circular Dichroism (CD) spectropolarimetry, molecular biology, and hydrogen exchange chemistry to measure the structures and dynamics of proteins, and to relate the information obtained to the actions of the proteins. The proteins under investigation are the membrane proteins, alamethicin and glycerol facilitator, and the intrinsically disordered protein, HIV-1 Transactivator of transcription.